MC-Transaction on Biotechnology, 2011, Vol. 3, No. 1, e4
Regulatory Checkpoints of Cell Cycle by Resveratrol to Anti-cancer Activities of Natural Polyphenols
Ming-Yeh Yang a, Chih-Jui Chang a, Liang-Yu Chen b*
a Department of Molecular Biology and Human Genetics, Tzu-Chi University (Hualien, Taiwan, R.O.C.)
b Department Biotechnology, School of Health Technology, Ming-Chuan University (Taoyuan, Taiwan, R.O.C.)
Corresponding author: Liang-Yu Chen [loknath @mail.mcu.edu.tw ]
Received 16 Oct 2011/Accepted 10 Nov 2011/Online published 13 Nov 2011
Abstract
Today, the ethnopharmacology is popular to treat disease, the herbs were used as considerable medicinal ingredients, but also the case with toxic substances is often due to improper poisoning, such as taking aristolochic acid caused kidney failure. Toxic risk evaluation of these plants in physiology is a very important issue to be facilitated by the reliable analytical method. Atractyloside (ATR) is one of a group of diterpenoid glycosides. The interest for these compounds was stimulated by the high toxicity of both glucosides, responsible of many deadly poisoning in past time. ATR occurs naturally in many Asteraceae plants, which are used as herbal medicines inOrient. The dried root of A. macrocephala and A. lancea are important crude drugs used in herbal medicine. ATR components were acidized and extracted from samples, then after the TMSI and pyridine derivatives for GC-MSD analysis. The ionic fragments in mass spectra were identified for TMS derivatives of ATR. The quantitative results showed that the ATR contents of 8980 ppm and 9230 ppm were detected in A. macrocephala and A. lancea, respectively. Others, the rare ATR was found in coffee beans for comparing.
Keyword: Carcinogensis, Cell cycle, Polyphenols
|
|